Advanced glycation end products (AGEs) are generated not only from glucose but also from several aldehydes such as methylglyoxal, glyoxal, and glycolaldehyde The aim of the present study was to investigate the effect of several aldehydes on human serum albumin (HSA) in terms of the physicochemicalChemically, an aldehyde / ˈ æ l d ɪ h aɪ d / is a compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon doublebonded to oxygen) with the carbon atom also bonded to hydrogen and to any generic alkyl or side chain R group The functional group itself (ie without the "R" side chain) is known as an aldehyde or formyl groupIn rodent SNpc, DA neurons can be divided into two subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH1A1) Here, we have shown that, in αsynuclein transgenic mice, a murine model of PDrelated disease, DA neurodegeneration occurs mainly in a dorsomedial ALDH1A1negative subpopulation that is also pron